Methicuris-P

Methicuris-P by Biocuris is a scientifically advanced neuropathic pain management formulation combining Pregabalin (Sustained Release – SR) and Methylcobalamin, developed under the trusted brand promise — “Quality with Integrity”. This dual-action tablet is specifically designed to address the root causes and debilitating symptoms of neuropathic pain, including burning sensation, tingling, numbness, and weakness associated with nerve damage.

Pregabalin (SR) is a potent anticonvulsant and analgesic that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. By reducing the influx of calcium into nerve terminals, Pregabalin decreases the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. This mechanism effectively calms hyperexcited neurons, reducing both neuropathic pain and seizure activity. The sustained-release (SR) formulation ensures steady plasma levels throughout the day, providing consistent pain relief with potentially fewer side effects and less frequent dosing compared to immediate-release versions.

Methylcobalamin is an active, neurologically active form of Vitamin B12 that plays an essential role in myelin sheath synthesis and repair. Myelin is the protective covering around nerve fibers that facilitates rapid signal transmission. In neuropathic conditions, myelin degradation leads to slowed or disrupted nerve impulses. Methylcobalamin promotes axonal regeneration, enhances neuronal survival, and improves nerve conduction velocity. Unlike cyanocobalamin (the common synthetic form), methylcobalamin is directly utilized by the nervous system without requiring hepatic conversion.

Together, Pregabalin (SR) provides symptomatic relief from pain, while Methylcobalamin addresses underlying nerve damage and regeneration. This synergistic combination is indicated for:

• Diabetic peripheral neuropathy – Burning, tingling, and numbness in hands and feet

• Post-herpetic neuralgia – Persistent pain following shingles

• Fibromyalgia – Widespread musculoskeletal pain

• Spinal cord injury-related neuropathic pain

• Peripheral neuropathy caused by alcohol, chemotherapy, or vitamin deficiencies

• Trigeminal neuralgia and other facial nerve pains

Methicuris-P offers comprehensive nerve care — reducing pain intensity, improving sleep quality, restoring nerve function, and enhancing overall quality of life for patients suffering from chronic neuropathic conditions.

Key Benefits:

• Dual Nerve Action – Pregabalin stops pain signals; Methylcobalamin repairs damaged nerves.

• Sustained Relief – SR formulation ensures 24-hour pain control with fewer doses.

• Myelin Regeneration – Supports rebuilding of protective nerve covering.

• Improves Sleep – Reduces nighttime pain and restlessness.

• Better Tolerability – SR technology minimizes dizziness and sedation side effects.